Histoid leprosy is a skin condition, a rare form of multibacillary leprosy See also[edit]. Leprosy · Skin lesion. References[edit]. ^ James, William D.; Berger. Histoid leprosy, an uncommon variant of lepromatous leprosy, develops usually as relapse in lepromatous patients who are on dapsone. Summary Histoid leprosy is a rare multibacillary form that presents with disseminated papule-nodular cutaneous lesions. To study the inflammatory infiltrate.

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J Indian Soc Teledermatol. Histoid, ldprosy clinical variant of multibacillary leprosy: It was first described by Wade in in patients from Phillipines. The AFB are not found in hitsoid formation, as they do not secrete any glial substance. However, specific histopathology of histoid leprosy differentiates it from LL type which shows macrophage granuloma with variable amount of foamy changes with innumerable bacilli and globi and Hietoid reaction which shows features of acute inflammation predominantly having neutrophils accompanied by edema along with granular AFB.

Clinically it is characterized by cutaneous and or subcutaneous nodules and papules, which are painless, firm, discrete, smooth, globular, skin-colored to histod, with apparently normal skin surrounding it.

Histopathological findings are unique. As the bacillary load is very high in these patients, they can form a potential reservoir of the infection. Closer view of Figure 1 Click here to view.

There is a male preponderance, and the average age at diagnosis is between 21 and 40 years. Author information Article notes Copyright and License information Disclaimer. Lepr Rev ; The lesions were flat-toped, nonscaly, flesh-colored to erythematous, almost symmetrical, normal-oedematous, soft-firm, to in size, painful for past 15 days.


The leproma consists of fusiform histiocytes arranged in a whorled, criss-cross, or storiform pattern. Hhistoid, Conflict of Interest: In more severely affected cases, mucosal and genital lesions have also been recorded. Within the histiocytes, plenty of AFB can be seen. It was good to carry out a Fite-Faraco stain for ruling out or confirming the diagnosis, especially as there was no clinical suspicion in our case.

Sehgal VN, Srivastava G.

These nodules often have central liquefaction necrosis with massive bacillary proliferation and neutrophilic infiltrations, characteristic of local exacerbation reaction [ 10 ]. There was history of fever associated with similar nodular eruption 1 year back which subsided on its own leaving behind hyperpigmentation at few areas.

Lepromatous leprosy of histoid type. Histoid leprosy Histoid leprosy is a skin condition, a rare form of multibacillary leprosy. Acknowledgement The authors would like to acknowledge and thank Dr.

Retrieved from ” https: The nodules were distributed on his low back, buttocks, arms, and abdomen. A prospective diagnostic study in 38 patients. Initial reports were associated with dapsone resistance and with relapse after dapsone monotherapy.

Histoid leprosy

In their most active form, histoid nodules expand rapidly, producing pseudocapsules of compressed collagen at their periphery. Reports are available with pronounced involvement of the face, the ears may show little change or may be unaffected [ 15 ]. There is male preponderance, and leprosu average age affected is between 21 and 40 years [ 2 ].


Histopathology of the nodule showed atrophic epidermis with a subepidermal grenz zone. Abstract Histoid leprosy is an uncommon entity with specific clinical, histopathological and bacteriological features.

Histoid leprosy is not uncommon in South India. Although rarely, but it is known to occur at age of ten years or youngerand as old as 84years [ 1 ]. Within the mass of spindle-shaped histiocytes, rounded-polygonal plump histiocytic cells with vacuolated cytoplasm along with occasional giant cells were noticed Figures 2 a — 2 c. There was no impairment of pain, touch, or temperature sensation.

Relapse as histoid leprosy after multidrug receiving therapy MDT: Relapse as histoid leprosy after receiving multidrug therapy MDT ; a report of three cases.

Case Reports in Pathology. Introduction Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae.

De Novo Histoid Leprosy in an Elderly: A Case Report and Review of the Literature

No family history and contact history with known case of leprosy. Palit A, Inamadar AC. Erythema nodosum leprosum rarely occurs in histoid Hansen. He had two episodes of epistaxis in the last 6 months that were treated leprosyy. Slit skin smear from the histoid lesions show abundant acid-fast bacilli in clusters, singles or tightly packed in macrophages. Routine investigations were within normal limits.