British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme’s activity. Dimercaprol Skeletal formula and ball and stick model of dimercaprol. Dimercaprol compound is useful for the treatment of potentially life-threatening acute arsenic poisoning as well. Internet URLs are the best.

You can make it easier for us to review and, hopefully, publish your contribution by keeping a few points in mind. Goals and duration of treatment. The effects were definitive and dramatic; the patients exhibited great improvement in accordance with marked increases in urinary copper excretion Cummings ; Denny-Brown and Porter It does, however, remove inorganic mercury from the kidneys; but is not useful in the treatment of alkylmercury or phenylmercury toxicity.

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Arsenic poisoning Dimercaprol Succimer. British anti-Lewisite is used in arsenic, gold, and mercury soluble inorganic compounds poisoning. Dimercaprol was first made during World War II. Keep Exploring Britannica Leewisite. Site license users, click the Site License Acces link on the Homepage at an authorized computer.

We welcome suggested improvements leiwsite any of our articles. Lorincz of the University of Michigan has no relevant financial leeisite to disclose.

British anti-Lewisite (dimercaprol): an amazing history.

abti The Royal Society of Chemistry. Dimercaprolalso called British anti-Lewisite BALis a medication used to treat acute poisoning by arsenicmercurygoldand lead. If you are a former subscriber or have registered before, please log in first and then click select a Service Plan or contact Subscriber Services.

Help us improve this article! Dimercaprol is more effective if its use is begun within two hours after ingestion of the toxic metal. Retrieved 8 December Rev Environ Contam Toxicol BAL was the drug of choice for treatment of intoxication with arsenic, antimony, mercury, and gold.

Dimercaprol | drug |

Retrieved from ” https: Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson’s disease. By using this site, you agree to lesisite Terms of Use and Privacy Policy. Our editors will review what you’ve submitted, and if it meets our criteria, we’ll add it to the article. Unfortunately, our editorial approach may not be able to accommodate all contributions.

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Eagle and Magnuson found that 48 patients with severe or mild symptoms of arsenical encephalopathy were effectively treated with BAL Eagle and Magnuson Dimercaprolalso called British anti-lewisite BALdrug that was originally developed to combat the effects of the blister gas lewisitewhich was used in chemical warfare.

By32 articles had been published or were in press on the therapeutic value of BAL Ord antj Plans for the possible production ofpounds per year were developed Waters and Stock Nonetheless, because it can have serious adverse effectsresearchers have also pursued development of anto toxic analogues.

BAL is not generally recommended for use today because more efficient and safer chelators for oral or parenteral administration have been developed Andersen ; Blanusa et al ; Archer At the bottom of the article, feel free to list any sources that support your changes, so that we can fully understand their context. C Risk not ruled out. Discover some of the most interesting and trending topics of Dimercaprol has been used as an adjunct in the treatment of the acute encephalopathy of lead toxicity.

Originally released November 30, ; last updated April 23, ; expires April 23,