Profil Adenokarsinoma Kolon di RSUP Prof Dr. R. D. Kandou dan Siloam Hospitals Periode Januari – Juni Pemberian Kombinasi 5FU-Leucovorin dengan Phaleria macrocarpa terhadap Proliferasi Sel dan Diameter Adenokarsinoma Kolon Tikus Sprague dawley. PROPOLIS TERHADAP KSPRESI PROTEIN CASPASE 8, APOPTOSIS, DAN PROLIFERASI PADA KULTUR SEL ADENOKARSINOMA KOLON (WiDr).

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CA Cancer J Clin, 55 3: Enter the email address you signed up with and we’ll email you a reset link. Conclusion P macrocarpa has the potential as immunostimulatory which can increase the effectiveness of 5FU-leucovorin chemotherapy in terms lowering the cell proliferation and decrease the diameter of adenocarsinoma colon of Sprague dawley rat.

Adenokarisnoma full drug information Capecitabine Xeloda Fluoropyrimidine carbamate prodrug from of 5-fluorouracil 5-FU.

National Comprehensive Cancer Network, Inc. Covalently binds to DNA with preferential binding to the N-7 position of guanine and adenine. Panitumumab becomes an option, or an alternative to cetuximab, for those patients who have tumors without KRAS mutation. Has activity as single agent that inhibits DNA replication and transcription. Sebagian besar pasien kanker kolorektal didiagnosis dalam stadium yang sudah tidak dapat dioperasi. Bevacizumab Avastin Murine derived monoclonal antibody that inhibits angiogenesis by targeting and inhibiting vascular endothelial growth factor Lolon.

In addition to 5-fluorouracil, oral fluoropyrimidines such as capecitabine Xeloda and tegafur are increasingly used as monotherapy or in combination with oxaliplatin Eloxatin and irinotecan Camptosar. For continuation therapy, use bevacizumab in combination with a fluoropyrimidine eg, 5-FU, capecitabine plus irinotecan or oxaliplatin-based chemotherapy Panitumumab Vectibix Recombinant human IgG2 kappa monoclonal antibody that binds to human epidermal growth factor receptor EGFR.

They determined that 6 hours or more of sitting per day was associated with an increase in mortality compared with only sitting 3 hours or less per day.


Penelitian dilakukan pada kultur sel WiDr dengan perlakuan pemberian dosis ekstrak ethanol propolis, kontrol positif 5-FUkombinasi ekstrak ethanol propolis dengan 5-FU, dan kontrol negatif tanpa aadenokarsinoma.


This study used a female Sprague dawley white rats were divided into 4 groups: Oxford, Willey Blackwell Press.

In an observational study of patients with stage III colon cancer, adjuvant chemotherapy reduced the risk of distant recurrence after surgery by about half. Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC.

Penelitian dilakukan dengan desain eksperimental laboratorik dengan desain post test only menggunakan tikus putih betina strain Sprague dawley dibagi menjadi 4 kelompok yaitu kelompok K kontrolP1 kelompok kemoterapiP2 kelompok P. Iranian Jour of Pharm Research; 10 2: Tumor kolon diperoleh dengan induksi 1,2-DMH subkutan. Food Chem Toxicol, Patients with mutant KRAS had no clinical benefit from adding cetuximab to chemotherapy and experienced only unnecessary toxicity.

Cetuximab may adenolarsinoma used as monotherapy or in combination with irinotecan Camptosar in patients with metastatic colorectal cancer addnokarsinoma to fluoropyrimidine and oxaliplatin therapy. This information is to adenokadsinoma derived from information on tumor biology, patient performance status, organ function, and pharmacogenomics testing.

Levamisole is no longer an appropriate component of adjuvant therapy. The authors concluded that adjuvant chemotherapy provides significant disease-free survival benefit because it reduces the recurrence rate particularly within the first 2 years of adjuvant therapy but with some benefit in years Less is known about effect of diet and physical activity on the recurrence of colon cancer.

Converted by the carboxylesterase enzyme to its active metabolite from, SN It is indicated for patients with metastatic colorectal cancer mCRC who have been previously treated with fluoropyrimidine- oxaliplatin- and irinotecan-based chemotherapy; an anti—vascular endothelial growth factor VEGF therapy eg, bevacizumab, ziv-aflibercept ; and, if KRAS wild type, an anti—epidermal growth factor receptor EGFR therapy eg, cetuximab, panitumumab [64].

Jurnal e-CliniC (eCl)

In another observational kloon from the same cohort of patients, patients were prospectively monitored and physical activity was recorded. Characteristic toxicity occurred in the FU schedules and thrombocytopenia and hand-foot syndrome were more prominent in the CAP regimens. Ongoing adjuvant trials are investigating additional risk stratification of stage II colon cancer based on clinicopathological and molecular markers ECOG trial.


ABC of colorectal cancer, 2nd ed. Boerl on Human Cancer Cell Lines. Current standard therapy for colon cancer involves combination chemotherapy. The National Academic Press; American Journal of Clinical Oncology. Regorafenib Stivarga Regorafenib is a tyrosine kinase inhibitor. Targeting Apoptosis Pathways in Cancer Therapy.

Binds to and stabilizes ternary complex of FdUTP intracellular active metabolite of fluoropyrimidines and thymidylate synthetase TSaugmenting cytotoxic effects of 5-fluorouracil. Surgery remains the top choice therapy with other modalities such as chemotherapy, radiation and immunotherapy as P macrocarpa Mahkota Dewa.

DNA mismatch repair enzymes are unable to recognize oxaliplatin-DNA adducts in contrast with other platinum-DNA adducts as a result of their bulkier size. Insidensi kanker kolon di seluruh dunia masih tinggi dan menjadi penyebab kematian terbanyak kategori penyakit tidak menular.

Though information adenokrasinoma results of adjuvant therapy in stage II and III colon cancer is limited, a data set assembled by the Adjuvant Colon Cancer Endpoints group with fluorouracil-based adjuvant therapy was recently analyzed. Immunomodulatory Action of Propolis on Macrophage Activation. Adjuvant Chemotherapy for Colorectal Cancer. Colon tumors induced by 1,2-DMH subcutaneously. Findings showed that the addition of radioembolization with yytrium significantly improved time to liver progression and median time to tumor progression.

Approval for continuation treatment was based on a study that showed maintenance of VEGF inhibition with bevacizumab plus standard second-line chemotherapy beyond disease progression has clinical benefits in patients with metastatic colorectal cancer.

Log In Sign Up. Journal of Surgery [Jurnalul de Chirurgie].